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The metabolic role of lactate dehydrogenase in the growth of diffuse large B cell lymphoma
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  • Na Zhou,
  • Qifeng Lu,
  • Jialin Zhang,
  • Wei Liu,
  • Jianwen Zou,
  • Jing Wang,
  • Lin Yang,
  • Qian Wang,
  • Hui Sun,
  • Tingting Hou
Na Zhou
Shandong Provincial Hospital

Corresponding Author:[email protected]

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Qifeng Lu
Shandong Provincial Hospital
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Jialin Zhang
Shandong First Medical University
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Wei Liu
Shandong Provincial Qianfoshan Hospital Shandong Medical and Health Key Laboratory of Emergency Medicine
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Jianwen Zou
Shandong Provincial Hospital
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Jing Wang
Shandong Provincial Hospital
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Lin Yang
Shandong Provincial Hospital
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Qian Wang
Shandong Provincial Hospital
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Hui Sun
Shandong Provincial Hospital
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Tingting Hou
Shandong Provincial Hospital
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Abstract

LDHA activation induces tumor by activating tumor proliferation, growth, invasion, and metastasis. Whether LDHA mediated tumor metabolism that upon DLBCL occur remains unknown. Here, we investigated how LDHA adopt tumor metabolism after activation to regulate DLBCL-inducible. Here, we investigated LDHA is highly expressed in peripheral blood mononuclear cell (PBMC) of DLBCL patients. Knockdown of LDHA results in an increase in the apoptosis of cells, suppression of cell growth and migration in LY1 cells. We show that LDHA gains a canonical enzyme activity to produce lactate and triggers NAD+ in DLBCL cells. Furthermore, p-STAT5 was identified as a downstream target of LDHA, and p-STAT5 protein level was significantly reduced related to decreased LDHA protein expression. Collectively, our findings identify the oncogenic role of LDHA in DLBCL and suggest that LDHA can be considered as a pivotal prognostic biomarker and a potential therapeutic target.