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Comparative Effectiveness of Minimally Invasive Surgery vs Open Surgery in neuroblastoma
  • +8
  • Zhang Jun,
  • Lan Qin,
  • Zhenzhen Zhao,
  • XiangRu Kong,
  • Yonggang Li,
  • Chao Yang,
  • Xiaobing Deng,
  • Liang Peng,
  • LinYa Lv,
  • ChangChun Li,
  • Shan Wang
Zhang Jun
Department of Surgical Oncology Children’s Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity

Corresponding Author:[email protected]

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Lan Qin
Department of Surgical Oncology Children’s Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity
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Zhenzhen Zhao
Department of Surgical Oncology Children’s Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity
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XiangRu Kong
Department of Surgical Oncology Children’s Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity
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Yonggang Li
Department of Surgical Oncology Children’s Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity
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Chao Yang
Department of Surgical Oncology Children’s Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity
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Xiaobing Deng
Department of Surgical Oncology Children’s Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity
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Liang Peng
Department of Surgical Oncology Children’s Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity
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LinYa Lv
Department of Surgical Oncology Children’s Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity
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ChangChun Li
Department of Surgical Oncology Children’s Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity
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Shan Wang
Department of Surgical Oncology Children’s Hospital of Chongqing Medical University National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity
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Abstract

Purpose: To explore the feasibility of minimally invasive surgery(MIS)used in the treatment of neuroblastoma. Methods: Selected NB patients were randomly assigned to the MIS group and the open surgery(OS) group. The operative details, major complications, and prognosis of the two groups were compared. Results: A total of 35 children undergoing MIS and 35 children undergoing open surgery were enrolled in this study. According to the INRGSS staging system, 30 patients were classified as stage L1, 32 as stage L2, and 8 as stage M. No statistical difference was found in the age of the children and the maximum diameter of the primary site tumor between the two groups. The bleeding volume in the OS group was significantly higher than that in the MIS group (P=0.006), The time to start postoperative feeding in the MIS group was significantly shorter than that in the OS group (P<0.001). No significant difference was found in the number of GTR between the MIS group and the OS group (P=0.246). The one-year survival rate and overall survival rate of the MIS group were 100% and 93.85%, while the OS group was 100% and 93.72%, respectively. Conclusion: MIS has more advantages than OS for suitable neuroblastoma, while the prognosis is almost the same. After gradually improving the indications for MIS, it should become the preferred surgical method for children within this range.