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A “Transformers”-Like Nanochain for Precise Navigation and Efficient Cancer Treatment
  • +4
  • Sichao Tian,
  • Qian Zeng,
  • Zhanglu Hu,
  • Weidong Zhang,
  • Zhuo Ao,
  • Dong Han,
  • Qing-Hua Xu
Sichao Tian
National University of Singapore Department of Chemistry
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Qian Zeng
National Center for Nanoscience and Technology
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Zhanglu Hu
Chinese Academy of Medical Sciences & Peking Union Medical College Institute of Medicinal Plant Development
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Weidong Zhang
Chinese Academy of Medical Sciences & Peking Union Medical College Institute of Medicinal Plant Development
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Zhuo Ao
National Center for Nanoscience and Technology
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Dong Han
National Center for Nanoscience and Technology
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Qing-Hua Xu
National University of Singapore Department of Chemistry

Corresponding Author:[email protected]

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Abstract

Integrated multimodal imaging in theranostics nanomaterials offers extensive prospects for precise and noninvasive cancer treatment. Precisely controlling the structural evolution of plasmonic nanoparticles is crucial in the development of photothermal agents. However, previous successes have been limited to static assemblies and single-component structures. Here, an activatable plasmonic theranostics system utilizing self-assembled 1D silver-coated gold nanochains (1D nanochains) is presented for precise tumor diagnosis and effective treatment. The absorbance of the adaptable core-shell chain structure can shift from visible to near-infrared (NIR) regions due to the fusion between nearby Au@Ag nanoparticles induced by elevated H 2O 2 levels in the tumor microenvironment (TME), resulting in the creation of a novel 3D aggregates with strong NIR absorption. With a high photothermal conversion efficiency of 60.2% at 808 nm, nanochains utilizing the TME-activated characteristics show remarkable qualities for photoacoustic imaging and significantly limit tumor growth in vivo. This study may pave the way for precise tumor diagnosis and treatment through customizable, optically tunable adaptive plasmonic nanostructures.