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Endothelial Cells and Blood-Brain Barrier (BBB): The Key Factors in Ineffective Reperfusion Outcomes
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  • zhao qianhui,
  • Xiaokun Geng,
  • enoch Kim,
  • Yuchuan Ding
zhao qianhui
Capital Medical University
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Xiaokun Geng
Capital Medical University

Corresponding Author:[email protected]

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enoch Kim
Wayne State University
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Yuchuan Ding
Wayne State University
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In the realm of neurointerventional treatment after ischemic stroke, ineffective reperfusion represents a significant challenge, with the integrity of the blood-brain barrier (BBB) serving as a pivotal determinant of outcomes. This review sheds light on the unique characteristics and roles of brain endothelial cells within the context of stroke with ineffective reperfusion. We address the distinctiveness of brain endothelial cells relative to their counterparts in different tissues, outlining their pathophysiological transformations, functional impairments, and inflammatory cascades post-stroke. The differential gene expression between brain endothelial cells and those from other organs provide a deeper understanding of their intrinsic roles in neuroprotective therapy. Looking ahead, exploring analogies between brain endothelial cells and those from organs with similar ischemia-reperfusion injury profiles could lead to innovative therapeutic strategies. This review highlights the paramount importance of understanding the nuanced roles of endothelial cells in mediating BBB dynamics, ultimately influencing reperfusion outcomes.
03 Feb 2024Submitted to European Journal of Neuroscience
03 Feb 2024Assigned to Editor
03 Feb 2024Submission Checks Completed
03 Feb 2024Review(s) Completed, Editorial Evaluation Pending
05 Feb 2024Reviewer(s) Assigned