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Skeletal Transformations of Terpenoid Forskolin Employing an Oxidative Rearrangement Strategy
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  • Shihao Cheng,
  • Chenhu Dong,
  • Yujie Ma,
  • Xiaoyu Xu,
  • Yu Zhao
Shihao Cheng
Nantong University
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Chenhu Dong
Nantong University
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Yujie Ma
Nantong University
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Xiaoyu Xu
Nantong University
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Yu Zhao
Nantong University

Corresponding Author:[email protected]

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Abstract

The skeletal transformations of diterpenoid forskolin were achieved employing an oxidative rearrangement strategy. A library of 52 forskolin analogues, including 12 CTD compounds and 40 SAR compounds with unique scaffolds/ring systems, was produced during the course of this work. Compounds 2c and 10c exhibited inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, with IC50 values of 0.3µM and 4.1µM.