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Evaluation of medication adherence in hypertension, dyslipidemia, and diabetes using health insurance claims: a population-based cohort study in Japan
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  • Minako Matsumoto,
  • Sei Harada,
  • Harufumi Ikuta,
  • Miho Iida,
  • Suzuka Kato,
  • Mizuki Sata,
  • Shibuki Takuma,
  • Yoshiki Ishibashi,
  • Naoko Miyagawa,
  • Moeko Hisamatsu,
  • Aya Hirata,
  • Kazuyo Kuwabara,
  • Ayano Takeuchi,
  • Daisuke Sugiyama,
  • Sayo Suzuki,
  • Tomonori Nakamura,
  • Tomonori Okamura,
  • Toru Takebayashi
Minako Matsumoto
Keio Gijuku Daigaku
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Sei Harada
Keio Gijuku Daigaku
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Harufumi Ikuta
Keio Gijuku Daigaku
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Miho Iida
Keio Gijuku Daigaku
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Suzuka Kato
Keio Gijuku Daigaku
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Mizuki Sata
Keio Gijuku Daigaku
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Shibuki Takuma
Keio Gijuku Daigaku
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Yoshiki Ishibashi
Keio Gijuku Daigaku
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Naoko Miyagawa
Keio Gijuku Daigaku
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Moeko Hisamatsu
Keio Gijuku Daigaku
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Aya Hirata
Keio Gijuku Daigaku
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Kazuyo Kuwabara
Keio Gijuku Daigaku
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Ayano Takeuchi
Chuo Daigaku
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Daisuke Sugiyama
Keio Gijuku Daigaku Kango Iryo Gakubu Daigakuin Kenko Management Kenkyuka
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Sayo Suzuki
Keio Gijuku Daigaku
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Tomonori Nakamura
Keio Gijuku Daigaku
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Tomonori Okamura
Keio Gijuku Daigaku
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Toru Takebayashi
Keio Gijuku Daigaku

Corresponding Author:[email protected]

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Abstract

Purpose: Hypertension (HT), dyslipidemia (DL), and diabetes mellitus (DM) are major risk factors for cardiovascular diseases. Despite the wide availability of medications to reduce this risk, poor adherence to medications remains an issue. The aim of this study is to evaluate medication adherence of prevalent users in these disease medications (HT, DL, DM) using claims data. Factors associated with non-adherence were also examined. Methods: Of 7,538 participants of the Tsuruoka Metabolomics Cohort Study, 3,737(HT: 2,724, DL: 2,137, DM: 665) were identified as prevalent users of these disease medications. Information on lifestyle was collected through a questionnaire. Adherence was assessed by a proportion of days covered (PDC) and participants with PDC ≥ 0.8 were defined as adherent. Predictors of non-adherence were determined by performing multivariable logistic regression. Results: Medication adherence differed by medication groups. Those with DL-only showed the lowest adherence (79.6%), followed by those with DM-only (81.7%) and those with HT-only (89.8%). The associations were observed especially among those with no comorbidities. Determinants associated with non-adherence in each medication group were skipping breakfast and poor understanding of medications among those with HT, females, having comorbidities, having the medical history of stroke, and drinking habit among those with DL, and skipping breakfast among those with DM. Conclusion: While participants showed high medication adherence, differences were observed across medication groups. The identified predictors of non-adherence could help target those in need of adherence support.
27 Jan 2024Submitted to Pharmacoepidemiology and Drug Safety
27 Jan 2024Review(s) Completed, Editorial Evaluation Pending
27 Jan 2024Assigned to Editor
27 Jan 2024Submission Checks Completed
01 Feb 2024Reviewer(s) Assigned