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Switchable Multicomponent Cyclization Reactions to Access Fluoroalkylated Dihydropyrimidines and Pyrimidines Under Sol-vent-Free Conditions
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  • Wanqing Zuo,
  • Zhizhen Zhu,
  • Yu Cheng,
  • Lingling Zuo,
  • Xiao Geng,
  • Zhifang Li,
  • Lei Wang
Wanqing Zuo
Hangzhou Normal University
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Zhizhen Zhu
Taizhou University
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Yu Cheng
Taizhou University
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Lingling Zuo
Taizhou University
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Xiao Geng
Taizhou University
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Zhifang Li
Hangzhou Normal University
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Lei Wang
Department of Chemistry, Huaibei Coal Teachers College, Huaibei, Anhui 235000, China

Corresponding Author:[email protected]

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The development of switchable solvent-free multicomponent reactions to build high-value-added products is an important demand for organic synthesis. Herein, we detailed the successful implementation of a switchable strategy for the construction of diverse 4-fluoroalkyl-1,4-dihydropyrimidines and 4-fluoroalkyl-pyrimidines via a solvent/additive-free [3 + 2 + 1] annulation, starting from readily available enamines, trifluoroacetaldehyde hydrate or 1-ethoxy-2,2-difluoroethanol and amidines hydrochloride. This reaction conforms to the concept of green synthesis, and provides a new avenue to access valuable fluorinated heterocycles.
Submitted to Chinese Journal of Chemistry
24 Jan 2024Assigned to Editor
24 Jan 2024Submission Checks Completed
24 Jan 2024Review(s) Completed, Editorial Evaluation Pending
27 Jan 2024Reviewer(s) Assigned
01 Feb 2024Editorial Decision: Revise Minor
01 Feb 20242nd Revision Received
02 Feb 2024Submission Checks Completed
02 Feb 2024Assigned to Editor
02 Feb 2024Review(s) Completed, Editorial Evaluation Pending
02 Feb 2024Editorial Decision: Accept