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Exploring the Potential of Bovine Colostrum as a Bioactive Agent in Human Tissue Regeneration: A Comprehensive Analysis of Mechanisms of Action and Challenges to be Overcome
  • Pedro Rassier dos Santos,
  • Rosana Basso Kraus,
  • Patrícia da Silva Nascente
Pedro Rassier dos Santos
Universidade Federal de Pelotas

Corresponding Author:[email protected]

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Rosana Basso Kraus
Universidade Federal de Pelotas
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Patrícia da Silva Nascente
Universidade Federal de Pelotas
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Abstract

Bovine colostrum is a rich source of bioactive compounds, including growth factors, that may promote tissue regeneration. Studies suggest it has potential therapeutic benefits in humans, but further research is needed to fully understand its mechanisms of action. This study aims to review scientific articles on the use of bovine colostrum as a bioactive agent for tissue regeneration in humans and twelve articles were selected. In vitro studies show that bovine colostrum can benefit cells by reducing cell proliferation and inducing differentiation. The concentration of colostrum used has a direct impact on the results, with no positive results observed at some high concentrations (20%). Extracted portions of colostrum (EVs and IMF) showed better results than the complete colostrum. In vivo studies show that bovine colostrum is a promising natural source for wound healing, as its bioactive factors help in the orderly progression of the healing process. However, some studies did not find any benefit related to tissue regeneration, and more research is needed to explore the full potential of colostrum in regenerative medicine and to develop more effective therapies for wound healing.