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The relationship between intra-amniotic sludge and the amniotic fluid proteome in a cohort of pregnant women with acute cervical insufficiency.
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  • Rachelle Govia ,
  • Kenzie Birse,
  • Adam Burgener,
  • Vanessa Poliquin,
  • Savas Menticoglou ,
  • Christy Pylypjuk
Rachelle Govia
University of Manitoba Max Rady College of Medicine
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Kenzie Birse
University of Manitoba Max Rady College of Medicine
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Adam Burgener
Case Western Reserve University
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Vanessa Poliquin
University of Manitoba Max Rady College of Medicine
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Savas Menticoglou
University of Manitoba Max Rady College of Medicine
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Christy Pylypjuk
University of Manitoba Max Rady College of Medicine

Corresponding Author:[email protected]

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Abstract

From 10 patients with acute cervical insufficiency and prospectively collected amniotic fluid, the relationship between intra-amniotic sludge (IAS) and proteomic profile is described. An abundance of keratinizing proteins were seen with IAS; without sludge, inflammatory proteins were predominant. Proteomic profiling may provide unique insights into management of these high-risk pregnancies.