The relationship between intra-amniotic sludge and the amniotic fluid
proteome in a cohort of pregnant women with acute cervical
From 10 patients with acute cervical insufficiency and prospectively
collected amniotic fluid, the relationship between intra-amniotic sludge
(IAS) and proteomic profile is described. An abundance of keratinizing
proteins were seen with IAS; without sludge, inflammatory proteins were
predominant. Proteomic profiling may provide unique insights into
management of these high-risk pregnancies.