Life-threatening Altered Mental Status Secondary to Memantine in an
Adolescent Undergoing Cranial Radiotherapy for Medulloblastoma
AbstractMemantine is used for neurocognitive protection in patients undergoing
cranial radiotherapy for central nervous system tumors and is assumed to
be well-tolerated. We present a case of memantine-induced altered mental
status requiring intensive care unit admission. An adolescent male with
relapsed, progressive medulloblastoma presented with severe altered
mental status shortly after the first fraction of palliative whole brain
radiotherapy. After extensive evaluation, his profound confusion was
attributed to memantine, which had been initiated one week prior.
Clinicians should be aware of the risk of altered mental status with
memantine, given the increased utilization and upcoming clinical trials
in pediatric patients.