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Expression of 15-Lipoxygenase isoenzymes and inflammatory cytokines in children with recurrent respiratory tract infections
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  • Yazhu Han,
  • Xiaoxue Liu,
  • Jun Wang,
  • Wanxin Xie,
  • Shuchang Wang,
  • Miaomiao Zhang,
  • Xue Li,
  • Xiaojuan Fan,
  • Ye Liu,
  • Yuling Zhang
Yazhu Han
Second Affiliated Hospital of Harbin Medical University
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Xiaoxue Liu
Harbin Medical University
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Jun Wang
Harbin Medical University
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Wanxin Xie
Harbin Medical University
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Shuchang Wang
Second Affiliated Hospital of Harbin Medical University
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Miaomiao Zhang
Second Affiliated Hospital of Harbin Medical University
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Xue Li
Second Affiliated Hospital of Harbin Medical University
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Xiaojuan Fan
Second Affiliated Hospital of Harbin Medical University
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Ye Liu
Harbin Medical University

Corresponding Author:[email protected]

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Yuling Zhang
Second Affiliated Hospital of Harbin Medical University
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Abstract

As one of the commonest diseases, respiratory tract infections (RTIs) are the major causes of high morbidity and mortality among children, especially recurrent respiratory tract infections (RRTIs). RRTIs can lead to prolong the recovery period, increase the cost and induce complications. 15-lipoxygenases (15-LOXs) have two isoenzymes: type 1 and type 2 (15-LOX-1, 15-LOX-2), which has been proved to be key mediators in inflammatory diseases. In this study, we analyzed the expression of 15-lipoxygenase isoenzymes and inflammatory cytokines in children with RRTIs, to determine their roles in active inflammation.