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The constricting effect of reduced coronary artery compliance on the left ventricle is an important cause of reduced diastolic function in patients with coronary heart disease
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  • Liang Lv,
  • Yannan Xu,
  • Qiong Zhang,
  • Shanshan Kan,
  • Xiaoming Chen,
  • Huajin Liu,
  • Hongwei Wang,
  • Changhua Wang,
  • Jiangwei Ma
Liang Lv
The Third Affiliated Hospital Southern Medical University or The Third School of Clinical Medicine Southern Medical University Guangzhou Guangdong China
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Yannan Xu
Anhui University of Science and Technology
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Qiong Zhang
Shanghai Fengxian Central Hospital
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Shanshan Kan
Anhui University of Science and Technology
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Xiaoming Chen
Anhui University of Science and Technology
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Huajin Liu
Shanghai Fengxian Central Hospital
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Hongwei Wang
Shanghai Fengxian Central Hospital
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Changhua Wang
Jining Medical University
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Jiangwei Ma
The Third Affiliated Hospital Southern Medical University or The Third School of Clinical Medicine Southern Medical University Guangzhou Guangdong China

Corresponding Author:[email protected]

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Abstract

Background: Previous studies of left ventricular diastolic function (LVDF) have focused on the decrease in active and passive diastolic function due to ischemic factors but have not investigated if the decrease in compliance of the coronary arteries that bypass the surface of the heart and travel between the myocardium could cause a constricting effect on the ventricular wall like that caused by myocardial fibrosis. Methods and Results: From October 2016 to October 2019, the Department of Cardiology of Fengxian District Central Hospital treated 581 patients diagnosed with coronary heart disease (CHD). They were divided into groups according to the degree of coronary stenosis, the number of stents and the length of stents implanted. It was concluded that there was a statistical difference in Gensini scores between patients in groups B, C and D (P<0.001). And multiple linear regression analysis showed that T was correlated with Gensini score and C-dp/dtmax(R=0.711, P<0.001). Grouping according to the site of stent implantation and the number of stents implanted, it was found out that the changes in T values before and after left anterior descending artery (LAD) stent implantation were greater than left circumflex artery (LCX) and right coronary artery (RCA) (P<0.001). And multiple linear regression revealed a correlation between T values and stent length, ventricular stiffness, and C-dp/dtmax(P=0.001). Conclusions: The decrease in compliance of the coronary arteries bypassing the surface of the heart and travelling between the myocardium would cause a constricting effect on the ventricular wall like that caused by myocardial fibrosis.