Objective: We describe physical and histological features, and the
molecular impact of mutation ITGA2B in a non-consanguineous China
family. In addition, we explore the fertility feasibility, pre-pregnancy
guidance of GT patients ,and how to avoid live births with GT. Methods:
We report two female patients, daughters of non-consanguineous parents.
The platelet aggregation rate showed a low pattern. TRIO whole exome
sequencing was requested. Results The patients received the LNG-IUS as
treatment for HMB. The study identified two genetic variants on
chr17:42457372 and chr17:42457057.