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Age-dependent Clinical Characteristics of Acute Lower Respiratory Infections in Young Hospitalized Children with Respiratory Syncytial Virus Infection
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  • Li Li,
  • heping wang,
  • Ailiang Liu,
  • jiehua chen,
  • Wenjian wang
Li Li
Shenzhen Children's Hospital

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heping wang
ShenZhen Children's Hospital
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Ailiang Liu
Shenzhen Children's Hospital
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jiehua chen
Shenzhen Children's Hospital
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Wenjian wang
Shenzhen Children's Hospital
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Abstract

Background. Human respiratory syncytial virus (HRSV) is the most common cause of acute lower respiratory infection (LRTI) in children. The main clinical manifestations are fever, cough, wheezing, and intercostal retractions. Its age-dependent clinical characteristics remain to be defined. Here, we investigated whether HRSV caused any age-related differences in clinical manifestations of LRTI. Methods. We enrolled 130 hospitalized children with LRTI caused by HRSV. These were stratified into four age groups. The main signs and symptoms and rates thereof were compared across the four age groups. Results. The incidence of pneumonia was the same in all four age groups. Patients in the 1–6 months old group experienced fever and the highest body temperature ≥ 38.5°C less frequently than patients in other age groups.The frequency of fever increased with age among the patients under 24 months old. Children over 12 months old experienced less wheezing, tachypnoea, hypoxia, and intercostal retractions than children in the 1–6 months old group. Conclusions. HRSV caused age-related differences in clinical manifestations of LRTI. Including fever may render HRSV cases more difficult to detect in young infants hospitalized with LRTI. The inclusion of wheezing, tachypnoea, and intercostal retractions in the diagnostic process in patients over 12 months old may lower the sensitivity to detect cases during the HRSV season.