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Overcoming Methotrexate Hypersensitivity through slow infusion
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  • Ali Alsaleemi,
  • Miranda Crealey,
  • Maeve Kelleher,
  • Aengus O’Marcaigh,
  • Aideen Byrne
Ali Alsaleemi
Children’s Health Ireland at Crumlin
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Miranda Crealey
Children’s Health Ireland at Crumlin
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Maeve Kelleher
Children’s Health Ireland at Crumlin, Dublin,
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Aengus O’Marcaigh
Children’s Health Ireland at Crumlin,
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Aideen Byrne
Children’s Health Ireland at Crumlin

Corresponding Author:[email protected]

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Abstract

Abstract Methotrexate is a vital medication in treating different types of malignancies. There are few reports of successful administration of intravenous methotrexate post adverse reaction by step-up desensitization. We share here, our experience in overcoming methotrexate hypersensitivity though administration of methotrexate by fixed rate infusion in an allergic child who failed a step-up methotrexate desensitization protocol. The outcome of this case suggests an underlying, non IgE mediated mechanism for the adverse reaction.