The Vitamin D Status in Children with Newly Diagnosed Acute
Lymphoblastic Leukaemia and its Potential Impact on Primary Symptoms of
Leukaemia and Course of Induction Treatment.
Background: The vitamin D deficiency is ubiquitous among children
population. Similar problem is recognized among paediatric patients with
acute lymphoblastic leukaemia. The purpose of this study was to analyze
the prevalence of vitamin D deficiency and investigate the connection
between vitamin D status and course of induction treatment of ALL.
Methods: A cross-sectional study including 59 patients with newly
diagnosed ALL from May 2017 until November 2020. Results: The vitamin D
insufficiency was found in 36% of patients. There were no seasonal
differences in vitamin D status. Patients with optimal 25(OH)D
concentration presented more profound thrombocytopenia (p=.015) and
required more frequent platelet transfusions (p=0.018). The good
prognosis factors as B phenotype and hyperdiploidy were also more
frequent among children with higher 25(OH)D concentration (p=0.01 and
p=0.014, respectively). Conclusion: The study displayed that patients
with higher serum concentration of 25(OH)D presented deeper
thrombocytopenia and needed more frequent transfusions. Moreover, those
patients showed higher rates of B-cell leukaemia and hyperdiploid
karyotype. We did not find any influence of potential sunlight exposure
(defined as the season of the year at admission) on serum 25(OH)D, which
supports the supplementing of vitamin D throughout the entire year.
Moreover, the supplementation of vitamin D seems to be safe in the
context of renal complications connected to calcium and phosphorus
imbalance as no correlation between their levels and 25(OH)D
concentration was found.