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left atrial sphericity predicts recurrence of atrial fibrillation after Pulmonary vein isolation: A Systematic Review and Meta-Analysis
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  • Liting Wei,
  • Zhiru Jin,
  • Decai Zeng,
  • Xiaofeng Zhang,
  • Qian Liang,
  • Jusheng Pei,
  • Ji Wu
Liting Wei
Guangxi Medical University First Affiliated Hospital
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Zhiru Jin
Guangxi Medical University First Affiliated Hospital
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Decai Zeng
Guangxi Medical University First Affiliated Hospital
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Xiaofeng Zhang
Guangxi Medical University First Affiliated Hospital
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Qian Liang
Guangxi Medical University First Affiliated Hospital
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Jusheng Pei
Guangxi Medical University First Affiliated Hospital
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Ji Wu
Guangxi Medical University First Affiliated Hospital

Corresponding Author:[email protected]

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Abstract

Background: Pulmonary vein isolation (PVI) has been the mainstay of catheter ablation for atrial fibrillation. Left atrial sphericity (LASP) was proposed as a new predictor of AF recurrence following ablation. While, evidence supporting this theory is conflicting. Objective: To clarify whether LASP is associated with increased risk of AF recurrence post PVI through a systematic review and meta-analysis. Methods: All studies evaluating the association between LASP and AF recurrence post-PVI were included by searching PubMed, Web of Science, Cochrane library, EMBASE and CNKI until August 1st, 2021. Two investigators performed screening, data extraction and quality assessment of the studies independently. Results: Ten articles with a total of 1608 patients were finally included. Results were presented as odds ratio (OR) with 95% confidence intervals (CI) and a random model was used. Higher LASP increases the risk of AF recurrence post PVI (HR =1.08, 95% CI1.02-1.14). Sub-group analysis showed that different modalities of measuring LASP (MRI and CT) had no significant impact on the odds. Funnel plot (Begg’s test, P=0.043) showed publication bias. Conclusion: LASP is associated with increased risk of AF recurrence post PVI