left atrial sphericity predicts recurrence of atrial fibrillation after
Pulmonary vein isolation: A Systematic Review and Meta-Analysis
Background: Pulmonary vein isolation (PVI) has been the mainstay of
catheter ablation for atrial fibrillation. Left atrial sphericity (LASP)
was proposed as a new predictor of AF recurrence following ablation.
While, evidence supporting this theory is conflicting. Objective: To
clarify whether LASP is associated with increased risk of AF recurrence
post PVI through a systematic review and meta-analysis. Methods: All
studies evaluating the association between LASP and AF recurrence
post-PVI were included by searching PubMed, Web of Science, Cochrane
library, EMBASE and CNKI until August 1st, 2021. Two investigators
performed screening, data extraction and quality assessment of the
studies independently. Results: Ten articles with a total of 1608
patients were finally included. Results were presented as odds ratio
(OR) with 95% confidence intervals (CI) and a random model was used.
Higher LASP increases the risk of AF recurrence post PVI (HR =1.08, 95%
CI1.02-1.14). Sub-group analysis showed that different modalities of
measuring LASP (MRI and CT) had no significant impact on the odds.
Funnel plot (Begg’s test, P=0.043) showed publication bias. Conclusion:
LASP is associated with increased risk of AF recurrence post PVI