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Recurrent fibrin-associated diffuse large B-cell lymphoma in a pediatric patient
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  • Paige Reilly,
  • Carlos Murga-Zamalloa,
  • Husain Batool Huzaifa,
  • Alexander Javois,
  • Peter Varga,
  • Martha Menchaca,
  • Naveen Imran,
  • Mary Lou Schmidt
Paige Reilly
University of Illinois at Chicago

Corresponding Author:[email protected]

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Carlos Murga-Zamalloa
University of Illinois at Chicago
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Husain Batool Huzaifa
University of Illinois at Chicago
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Alexander Javois
University of Illinois at Chicago
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Peter Varga
University of Illinois at Chicago
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Martha Menchaca
University of Illinois at Chicago
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Naveen Imran
University of Illinois at Chicago
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Mary Lou Schmidt
University of Illinois Medical Center at Chicago
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Abstract

Fibrin-associated diffuse large B-cell lymphoma is an exceptionally rare neoplasm associated with Epstein-Barr virus. It is distinguished by an indolent growth pattern within confined spaces and has a predilection for prosthetic cardiac valves, implants, and thrombi. The case is an immunocompetent 7-year-old with complex congenital heart disease and recurrent primary cardiac FA-DLBCL in association with two bovine bioprosthetic pulmonary valves. Children with complex CHD have an increased risk of lymphoma and cardiac prosthetic devices may provide environments for FA-DLBCL to occur. Pediatric oncologists must be alerted to the risk of this incredibly rare lymphoma subtype, especially among children with CHD.