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ACUTE LYMPHOBLASTIC LEUKAEMIA OCCURRED 21 YEARS AFTER A FIRST DIAGNOSIS IN A DOWN SYNDROME PATIENT SUCCESFULLY TREATED WITH BLINATUMOMAB
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  • Lorenzo Rizzo,
  • Sabina Chiaretti,
  • Irene Della Starza,
  • Akram Taherinasab,
  • Lucia Anna De Novi,
  • Giovanni Cazzaniga,
  • Simona Songia,
  • Maria Stefania De Propris,
  • Maria Luisa Moleti,
  • Anna Maria TESTI,
  • robin foà
Lorenzo Rizzo
University of Rome La Sapienza
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Sabina Chiaretti
University of Rome La Sapienza
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Irene Della Starza
University of Rome La Sapienza
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Akram Taherinasab
University of Rome La Sapienza
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Lucia Anna De Novi
University of Rome La Sapienza
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Giovanni Cazzaniga
Centro di Ricerca Tettamanti, Clinica Pediatrica, Università di Milano
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Simona Songia
Centro di Ricerca Tettamanti, Clinica Pediatrica, Università di Milano
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Maria Stefania De Propris
University of Rome La Sapienza
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Maria Luisa Moleti
University of Rome La Sapienza
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Anna Maria TESTI
University of Rome La Sapienza

Corresponding Author:[email protected]

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robin foà
University of Rome La Sapienza
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Abstract

Down syndrome (DS) acute lymphoblastic leukemia (ALL), more frequent in pediatric age than in adulthood, still have a worse outcome compared with non-DS population, mainly due to their intrinsic susceptibility to chemotherapeutic drugs toxicity. Furthermore, in the last years, it has been shown that the overexpression of CRLF2 and a Ph-like signature are relatively more frequent in DS patients. We report a case of a DS patient who developed a Ph-like ALL, 21 years after a first diagnosis of B-ALL, successfully treated with blinatumomab after failure of conventional chemotherapy.