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Trend of consumption of the antifungal agents fluconazole, voriconazole and itraconazole in an adult ICU from 2009 to 2020 in a university hospital in Salvador-Bahia
  • Federico Marilia Marilia Pinto,
  • Aníbal de Freitas Júnior

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Federico Marilia Marilia Pinto
Universidade Estadual de Feira de Santana
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Aníbal de Freitas Júnior
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Invasive fungal infections have a high morbidity and mortality rate in Brazil. In this aspect, antifungal agents used in hospital units represent the only treatment alternative. This work aims to to analyze the trend of antifungal consumption in an Intensive Care Unit (ICU) for adults, in a university hospital, in Salvador-Bahia. Retrospective descriptive study, which evaluated the trend of consumption of antifungal agents in the adult ICU based on the consumption records of standardized systemic antifungals that were dispensed to patients over the period and expressed in Defined Daily Dose (DDD)/100 patients -day. The most consumed antifungals, in descending order were: Fluconazole (91.58%; p= 0.1726) voriconazole (7.2%; p=0.9356) and itraconazole (0.45%). Antifungals were widely used in the adult ICU of the university hospital and the growing consumption trend demonstrates that it is necessary to monitor and promote the rational use of these drugs, since the inadequate and/or excessive use, in addition to burdening the health system , can increase fungal resistance to the only agents available to fight fungal infections.