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Straightforward synthesis of quinazolin-4(3H)-ones via visible light-induced condensation cyclization
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  • Wuji Sun,
  • Xue Ma,
  • Yuqi Pang,
  • Lifeng Zhao,
  • Qidi Zhong,
  • Chunyan Liu,
  • Qiangwen Fan
Wuji Sun
North China University of Science and Technology
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Xue Ma
North China University of Science and Technology
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Yuqi Pang
North China University of Science and Technology
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Lifeng Zhao
North China University of Science and Technology
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Qidi Zhong
North China University of Science and Technology
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Chunyan Liu
North China University of Science and Technology

Corresponding Author:[email protected]

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Qiangwen Fan
East China University of Technology
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Abstract

A green, simple and efficient method is developed for the synthesis of quinazolin-4(3H)-ones via visible light-induced condensation cyclization of 2-aminobenzamides and aldehydes under visible light irradiation. The reaction proceeds using fluorescein as photocatalyst in the presence of TBHP without the need for metal catalyst. In addition, this reaction tolerates a broad scope of substrates and could afford a variety of desirable products in good to excellent yields. Thus, the present synthetic method provides a straightforward strategy for the synthesis of quinazolin-4(3H)-ones.