Adipocyte: an assistant to breast cancer development and a potential
treatment strategy for breast cancer
AbstractWith obesity becoming an epidemic, adipocytes have attracted widespread
attention. Growing studies have shown that the function of adipocytes is
far more than storing energy. As endocrine organs, adipocytes play a
pivotal role in the occurrence and prevention of many diseases.
Especially it can secrete cytokines and mediate chronic inflammation,
making it one of the assistants of tumor development. Breast cancer is
the main cause of cancer death in women, and its development has
experienced proliferation, invasion, migration, metastasis, and drug
resistance. It reports that the mammary gland is rich in adipocytes. And
adipocytes can communicate with breast cancer cells and play a pivotal
role in breast cancer development. It displays that adipocytes promote
the proliferation, metastasis, and drug resistance of breast cancer.
This suggests that focusing on adipocytes may be helpful for tumor
treatment. In this paper, we reviewed the regulation mechanism of
adipocytes on the development of breast cancer and proposed strategies
to treat breast cancer. And this may provide a research basis for the
prevention and treatment of breast cancer.