loading page

Depressed sodium with antidepressant: A rare side effect from duloxetine in a child with acute leukemia
  • Muhammad Baig,
  • Kevin Madden,
  • Karen Moody
Muhammad Baig
Loma Linda University Medical Center

Corresponding Author:[email protected]

Author Profile
Kevin Madden
University of Texas MD Anderson Cancer Center
Author Profile
Karen Moody
MD Anderson Children’s Cancer Hospital
Author Profile


Duloxetine is indicated for the treatment of chemotherapy induced neuropathic pain in adults. It is also indicated for anxiety, depression and fibromyalgia in children. A rare side effect of syndrome of inappropriate antidiuretic hormone (SIADH) secretion has been reported in adults but not in pediatrics or pediatric oncology patients. We present a case of a 10-year-old child with acute lymphoblastic leukemia who developed SIADH after duloxetine was given for chemotherapy-induced neuropathic pain and co-morbid anxiety. The SIADH resolved after duloxetine was stopped. This case highlights a rare side effect of duloxetine and caution should be taken when prescribing duloxetine to children.