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Depressed sodium with antidepressant: A rare side effect from duloxetine in a child with acute leukemia
  • Muhammad Baig,
  • Kevin Madden,
  • Karen Moody
Muhammad Baig
Loma Linda University Medical Center

Corresponding Author:[email protected]

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Kevin Madden
University of Texas MD Anderson Cancer Center
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Karen Moody
MD Anderson Children’s Cancer Hospital
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Abstract

Duloxetine is indicated for the treatment of chemotherapy induced neuropathic pain in adults. It is also indicated for anxiety, depression and fibromyalgia in children. A rare side effect of syndrome of inappropriate antidiuretic hormone (SIADH) secretion has been reported in adults but not in pediatrics or pediatric oncology patients. We present a case of a 10-year-old child with acute lymphoblastic leukemia who developed SIADH after duloxetine was given for chemotherapy-induced neuropathic pain and co-morbid anxiety. The SIADH resolved after duloxetine was stopped. This case highlights a rare side effect of duloxetine and caution should be taken when prescribing duloxetine to children.