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Oxygen Therapy Confers Little Benefit to Patients with Acute ST-Segment Elevation Myocardial Infarction: A Systematic Review and Meta-Analysis
  • xinjuan Wang,
  • Cuiping Li
xinjuan Wang
Taizhou University Medical School

Corresponding Author:[email protected]

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Cuiping Li
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Abstract

Abstract Objective: To investigate the clinical benefit of oxygen therapy in patients with acute ST-segment elevation myocardial infarction (STEMI). However, ST elevation myocardial infarction has not been reported or controversial Methods: We searched PubMed, Embase, and the Cochrane Library from database inception to June 2020 to identify randomized controlled trials (RCTs) on oxygen therapy in acute STEMI. Literature screening, data extraction, and study quality assessment were independently carried out by two authors according to the predefined eligibility criteria, and RevMan 5.3 analysis software was utilized for all analyses. Results: Finally, 5 RCTs with 4,824 STEMI patients were eligible for further meta-analysis. The results demonstrated that oxygen therapy exerted non-significant effects in reducing the risks of short-term all-cause mortality (RR = 1.21, 95% CI: 0.80 to 1.53, P = 0.53), cardiac arrest (RR = 1.20, 95% CI: 0.94 to 1.54, P = 0.79), recurrent myocardial infarction (RR = 0.68, 95% CI: 0.43 to 1.08, P = 0.10), and cardiogenic shock (RR = 0.81, 95% CI: 0.58 to 1.15, P = 0.24) and the incidence of other outcome indicators of acute STEMI. Conclusions: Oxygen therapy does not bring more benefits than adverse effects on patients with acute STEMI. Personalized oxygen treatment based on their dynamic oxygen saturation is recommended for hypoxic patients. Key words: Acute ST-segment elevation myocardial infarction; oxygen therapy; randomized controlled trial; meta-analysis