Clinical manifestation of supra-large range non-perfusion area diabetic
retinopathy: a specific severe diabetic retinopathy
Objective: The aim of this study was to describe the clinical
manifestation of a specific type of diabetic retinopathy (DR),
supra-large range non-perfusion area diabetic retinopathy (SLRNPA DR).
Methods: This is a retrospective consecutive case series study. 260 eyes
from 236 patients who suffered from diabetic retinopathy and underwent
pars plana vitrectomy in the department of ophthalmology, Qingdao
Municipal Hospital from February 2016 to June 2019 were enrolled. Fundus
fluorescein angiography (FFA) was used after surgery to determine
whether it was SLRNPA DR or non-SLRNPA DR. The demographics and relevant
clinical data of these patients were carefully collected. Results: In
this cohort, 41 eyes from 22 patients were diagnosed as SLRNPA DR, which
was 15.77% of all eyes. When compared with non-SLRNPA DR patients,
SLRNPA DR patients were more male, younger age and onset, and more
likely to have history of smoking, have other comorbidities, have higher
HbA1c. As for SLRNPA DR eyes, higher probability of occurrence of
neovascular glaucoma (NVG) and diabetic keratopathy (DK) was found.
There eyes were more likely to need anti-VEGF therapy before surgery,
more likely to need silicon oil or gas tamponade during the surgery, and
more likely to be suffered from persistent corneal epithelial erosion
(PCEE) and recurrence of NVG. Conclusions: SLRNPA DR is a specific type
of DR, which might be more severe than common kinds of DR. We need pay
more attention to SLRNPA DR during our clinical process.