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FACIAL ERYTHEMA MAY NOT ALWAYS BE A MANIFESTATION OF THE PRIMARY CONDITION IN CONNECTIVE TISSUE DISEASES: KEEP DEMODEX IN MIND!
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  • Abdulsamet Erden,
  • Berkan Armağan,
  • Serdar Güven,
  • Özlem Karakaş,
  • Fatma Erden,
  • Bahar Özdemir,
  • Ahmet Omma,
  • Orhan Kucuksahin
Abdulsamet Erden
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Berkan Armağan
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Serdar Güven
Ankara City Hospital
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Özlem Karakaş
Ankara City Hospital

Corresponding Author:[email protected]

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Fatma Erden
Yildirim Beyazit Universitesi Tip Fakultesi
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Bahar Özdemir
Ankara City Hospital
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Ahmet Omma
Ankara City Hospital
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Orhan Kucuksahin
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Abstract

ABSTRACT Objective: Aim of this study was to investigate frequency of Demodex infestation and clinical implications in connective tissue disease patients with facial erythema. Methods: Patients who diagnosed with a connective tissue disease and had facial erythema were consecutively enrolled in the study. An age and gender matched control group was formed from healthy volunteers. Presence of Demodex was investigated by standardized skin surface biopsy. Number of Demodex mites over 5 per centimeter square was considered meaningful for infestation. Topical or systemic metronidazole treatment was given to the connective tissue disease patients with Demodex infestation. Facial erythema visual analog scale was questioned in patients at treatment onset and one month after. Results: A total of 31 connective tissue disease patients with facial erythema were enrolled. Control group included 31 healthy volunteers. Demographics and comorbidities were similar between groups. Demodex infestation was present in 58.1% of the connective tissue disease group and in 25.8% of the control group (p=0.01). Pruritus was the most common symptom in patients with infestation. Median (IQR) facial erythema visual analog scale score was 6 (3) at treatment onset and was 2 (2.5) one month after (p <0.001). Conclusion: When evaluating facial cutaneous lesions, Demodex infestation should not be overlooked in a patient group like connective tissue diseases with dysfunctional immune system.