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SUBLINGUAL METHYLCOBALAMIN TREATMENT IS AS EFFECTIVE AS INTRAMUSCULAR AND PERORAL TREATMENT IN 0-3 YEARS OLD CHILDREN
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  • Betül Kılıç,
  • Serhat KILIÇ,
  • Elif Şahinoğlu Eroğlu,
  • Eylem Gül,
  • Fatma Burcu Belen Apak
Betül Kılıç
Baskent Universitesi Ankara Hastanesi

Corresponding Author:[email protected]

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Serhat KILIÇ
Baskent Universitesi Ankara Hastanesi
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Elif Şahinoğlu Eroğlu
Baskent Universitesi Ankara Hastanesi
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Eylem Gül
Baskent University Faculty of Medicine, Department of Biostatistics, Ankara, TURKEY
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Fatma Burcu Belen Apak
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Abstract

Objectives: Vitamin B12 deficiency is a cause of preventable growth and developmental retardation in children. In this respect, alternative methods such as oral and sublingual treatments are being tried. We aimed to compare the efficacy of oral, sublingual and intramuscular vitamin B12 treatments in children aged 0-3 years. Methods: The study included 158 patients with serum vitamin B12 deficiency (serum vitamin B12 level <300 pg/ml) aged 0-3 years retrospectively. According to the vitamin B12 treatment modalities, the patients were divided into three groups as oral cyanocobalamin (group 1), sublingual methyl-cobalamin (group 2) and intramuscular cyanocobalamin (group 3). Results: The mean values of vitamin B12 levels increased to above 300 pg/ml in all of three groups . This increase was statistically significant for Group 1,2 and 3 (p<0.05). Conclusion: Sublingual methyl-cobalamin was determined as effective as oral and intramuscular cyanocobalamin improving vitamin B12 levels aged 0-3 years.