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Prescription Pattern and Management of Comorbid Conditions of HIV-positive Patients in a Tertiary Care Teaching Hospital: A Retrospective Study
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  • Seethalakshmi H,
  • Raghav Sharma,
  • Bharathraj KC,
  • Prashant Nayak,
  • Shreyas K
Seethalakshmi H
NGSM Institute of Pharmaceutical Sciences
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Raghav Sharma
KS Hegde Medical Academy
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Bharathraj KC
NGSM Institute of Pharmaceutical Sciences
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Prashant Nayak

Corresponding Author:[email protected]

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Shreyas K
NGSM institute of Pharmaceutical Sciences
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Abstract

Objective: During the management of Human Immunodeficiency Virus infection, comorbidities such as opportunistic infections and other non-communicable diseases may occur which require co-medications and monitoring. The objective of this study was to assess the prescription pattern of antiretroviral drugs, comorbidities, and their management in HIV positive patients. Methods: This retrospective observational study evaluated the medical records of 150 in-patients diagnosed with HIV infection. The antiretroviral drugs prescribed for these patients were studied and the reported comorbidities and co-medications were evaluated. Results: The mean age of study population was 45.75 ± 10.15 years and a majority of the patients (40.7%) belonged to the 40-49 years’ age group. Anti-Retroviral Therapy (ART) was prescribed in 72% of the patients of which 88.0% were prescribed first-line ART. The most common ART regimen was istenofovir + lamivudine + efavirenz (50.93%), and lamivudine (88.0%) was the most commonly prescribed antiretroviral drug. On an average, each patient had 2.07 ± 1.072 comorbidities and tuberculosis was the most frequently encountered comorbidity (30.0%). Antiulcerants and antiflatulents (87.3%) were the most extensively used co-medications. A mean of 8 co-medications were prescribed per patient. Conclusions: This study is another evidence where comorbidities are common occurrence in HIV patients of all age groups and receive significant amount of co-medications. Hence, excellent care should be taken during prescribing and management of HIV- infected patients.