EPO has been found to be protective to multiple injuries long time ago.
Discovery of the so-called tissue protective receptor “EPOR/βcR” is
astonishing among EPO researchers. βcR is a receptor subunit shared by
IL-3/IL-5/GM-CSF and EPO, but no attention has been paid to these three
cytokines in EPO research. This article unprecedentedly presented that
potential relations between EPO and IL-3/IL-5/GM-CSF should be highly
valued. We respectively compared GM-CSF and IL-3 to EPO/EPO derivatives,
and summarized similar and opposite functions between these two
cytokines and EPO/EPO derivatives. Here, drawbacks of the EPOR/βcR
theory were deeply discussed and new hypothesis about the mechanism of
EPO protection was proposed. In a word, referring to stagnation of EPO
research and defects of current recognition, reassessment of our
understandings about EPO’s protective function is of great urgency.