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Reevaluation of EPO and its Derivatives Centering on β Common Receptor
  • Yumin Luo,
  • Rongliang Wang,
  • Zhenhong Yang
Yumin Luo
Cerebrovascular Diseases Research Institute, Xuanwu Hospital of Capital Medical University

Corresponding Author:[email protected]

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Rongliang Wang
Institute of Cerebrovascular Diseases Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China
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Zhenhong Yang
Institute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China
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Abstract

EPO has been found to be protective to multiple injuries long time ago. Discovery of the so-called tissue protective receptor “EPOR/βcR” is astonishing among EPO researchers. βcR is a receptor subunit shared by IL-3/IL-5/GM-CSF and EPO, but no attention has been paid to these three cytokines in EPO research. This article unprecedentedly presented that potential relations between EPO and IL-3/IL-5/GM-CSF should be highly valued. We respectively compared GM-CSF and IL-3 to EPO/EPO derivatives, and summarized similar and opposite functions between these two cytokines and EPO/EPO derivatives. Here, drawbacks of the EPOR/βcR theory were deeply discussed and new hypothesis about the mechanism of EPO protection was proposed. In a word, referring to stagnation of EPO research and defects of current recognition, reassessment of our understandings about EPO’s protective function is of great urgency.