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Evaluating serum Neuregulin 4 as a non-invasive biomarker in Egyptian patients with Non-Alcoholic Fatty Liver Disease
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  • Tarek H. Gado,
  • Sara A. Asal,
  • Fatma H. Abdelraouf ,
  • Rasha M. Abdel Samie
Tarek H. Gado
Cairo University
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Sara A. Asal
Cairo University
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Fatma H. Abdelraouf
Cairo University
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Rasha M. Abdel Samie
Cairo University

Corresponding Author:[email protected]

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Abstract

Abstract Background: Non-alcoholic fatty liver disease (NAFLD) spectrum ranges from simple hepatic steatosis to non-alcoholic steatohepatitis. Considering the restrictions of liver biopsy, various serological biomarkers have recently emerged for non-invasive diagnosis of NAFLD. Aim of work: Evaluating the association between serum neuregulin 4 and NAFLD and the use serum Neuregulin 4 (Nrg4) as a non-invasive marker for diagnosis of NAFLD. Patients and Methods: Sixty-three Egyptian NAFLD patients and 63 control subjects were enrolled Detailed history taking, thorough clinical examination including anthropometric measures (Body mass index (BMI) and waist circumference) and laboratory investigations including complete blood count, lipid profile (total cholesterol, LDL-C, HDL-C, triglycerides), serum albumin, transaminases, bilirubin levels, hepatitis markers (anti-HCV antibodies and HBsAg), anti-nuclear antibodies and anti-smooth muscle antibody were performed. Measurement of serum Neuregulin 4 (Nrg4) by ELISA and non-invasive NAFLD scores such as NAFLD fibrosis score and FIB4 score were applied to all patients. Results: There was a statistically significant difference between cases and controls regarding the BMI, waist circumference, haemoglobin level, total leucocytic count, total cholesterol, LDL-C, HDL-C, and serum triglycerides levels. Nrg4 was significantly decreased in NAFLD patients as compared to controls. Moreover, Nrg4, total cholesterol, LDL-C levels were statistically significant independent predictors of NAFLD. No significant differences were observed between Nrg4 level and the variable stages of hepatic fibrosis by NAFLD fibrosis score. Conclusion: Decreased serum Nrg4 level is frequent in NAFLD patients and is an independent predictor of NAFLD suggesting that Nrg4 might have a potential role in prevention and treatment of NAFLD. Keywords: Neuregulin-4, Non-alcoholic fatty liver disease, Non-invasive biomarker, Egyptian patients.