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Heart-on-a-chip based on machine vision and artificial intelligence
  • Xin Ma,
  • Natan Barros,
  • Ji Zhao
Xin Ma
Tiangong University

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Natan Barros
Terasaki Institute for Biomedical Innovation
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Ji Zhao
Tiangong University
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Abstract

The research and development of cardiac drugs often focus on drug efficacy and side effects. However, traditional drug detection model of two-dimensional cell culture in Petri dish can not meet the need of drug industry with lower cost and quick time. Heart-on-a-chip (HOC) as an alternative physiological model to simulate human heart microenvironment in vitro now is accelerating medicine Research and Development, and is developing towards the direction of multi-disciplinary integration. The technical fields involved include biology, chemistry, material, and especially AI. Biosensor and machine vision, as frequently used engineering methods in computer science and bioelectronics, can also be used in HOC at present, which undoubtedly improve the rich functions of HOC and the prediction ability of drug safety and efficiency in pharmacology research, and definitely provide big data for real-time data analysis. In this paper, we firstly introduce the physiological structure of heart, and secondly clarify the heart-on-a-chip and its working principle, materials, and fabrication, furtherly present some interesting samples of heart-on-a-chip combined with biosensor and machine vision, and finally put forward the research vision and challenges in the future.