The Interleukin 6 (IL-6) blockade for coronavirus disease 2019
(COVID-19) In Lung
COVID-19 has caused global pandemics since the emergent outbreak and
resulted in a large number of deaths. IL-6, as an important autoimmune
cytokine, had been suggested for the treatment of acute respiratory
distress syndrome (ARDS) patients in COVID-19. A review of the relevant
literature revealed more than one role for IL-6 in the lung infection
because of its diverse biological effects. It may have a variety of
different physiological functions in the development of lung infection.
We have summarized its role in different progress of COVID-19, including
lung infection, pneumonia, ALI, pulmonary fibrosis, and lung translation
and even lung cancer. This will facilitate a deeper understanding of the
role of IL-6 in the treatment of COVID-19.