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Novel early predictor marker for neonatal bronchopulmonary dysplasia
  • Mohamed Elfarargy,
  • Ghada Al-Ashmawy
Mohamed Elfarargy
Tanta University Faculty of Medicine

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Ghada Al-Ashmawy
Tanta University Faculty of Pharmacy
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Background: Neonatal bronchopulmonary (BPD) is a serious chronic respiratory disease in neonates and is associated with long term problems and even death in neonates. Objective: Early detection of serum vitamin A levels in neonates as a predictor for neonatal BPD. Patients and methods: A retrospective case-control study, was done on 30 neonates who were hospitalized in neonatal intensive care unit (NICU) of Tanta University Hospital (TUH) suffering from bronchopulmonary dysplasia (BPD) (patient group) and 30 healthy neonates (control group). Detection of serum vitamin A (retinol) was done for all studied neonates within the first four hours after birth. Results: It showed statistically significant difference (SSD) in the serum RT levels between the patient and control group (P=0.001) and also significant negative correlation between serum RT levels and grades of BPD (P=0.005*). It showed that in the cases of neonatal BPD, the cut off value of serum RT levels was 0.84 μmol/L, AUC was 0.836, Sensitivity was 87 %, Specificity was 83 %, PPV was 84%, NPV was 86% and Accuracy was 85%. Conclusion Neonatal serum vitamin A levels were low in BPD neonates and may be used as a predictor for BPD development. Recommendation: Serum vitamin A levels in neonates could be used as a novel predictor marker for neonatal BPD.