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New interpretation of TB-IGRAS quantification of peripheral blood IFN-γ in the progression of lung cancer
  • Yizhi Peng,
  • Sheng Yin,
  • Min Wang
Yizhi Peng
Second Xiangya Hospital
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Sheng Yin
Second Xiangya Hospital
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Min Wang
Second Xiangya Hospital

Corresponding Author:[email protected]

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Abstract

Abstract: Objective: To explore the new interpretation of quantification of peripheral blood IFN-γ by TB-IGRAS in various cancers and the progression of lung cancer ; Methods: A total of 389 patients and 127 healthy volunteers admitted to the Second Xiangya Hospital from June 2018 to April 2021 were recruited, including 259 patients with lung cancer, 27 patients with liver cancer, and 103 patients with hematologic tumors. 10mL heparin sodium was collected for anticoagulation and TB-IGRAS was performed within 24 hours. SPSS version 26.0 software was used to analyze these results . Results: The concentrations of IFN-γ in healthy control group, lung cancer group, liver cancer group and hematological malignancy group were 517.91(352.83-750.75), 1022.61(253.41-2872.23), 2764.87(953.23-7084.61) and 11106.41(259.41-3326.28)pg/mL, respectively. The IFN-γ concentration in lung cancer group was higher than that in healthy control group (P <0.001), liver cancer group (P =0.01) and hematological malignancy group (P < 0.001). The concentrations of IFN-γ in the non-metastatic lung cancer group and the metastatic group were 2893.57(1092.94-7592.89) pg/mL and 1554.63(308.43-4927.04) pg/mL, respectively, the concentrations of IFN-γ in the non-metastatic group were higher than those in the metastatic group (P <0.001). Conclusion: The quantification of IFN-γ produced by peripheral blood T cells after PHA stimulation by TB-IGRAS test might explain, to some extent, the different responsiveness of various cancers to ICI treatment. Monitoring lung cancer patients might help to judge whether they have a tendency to further metastasis.