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High rate of extreme thrombocytosis indicates bone marrow hyperactivity and splenic dysfunction among congenital diaphragmatic hernia patients
  • +2
  • Hannah Gu,
  • Matthew Devine,
  • Holly Hedrick,
  • Natalie Rintoul,
  • Christopher Thom
Hannah Gu
The Children's Hospital of Philadelphia
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Matthew Devine
The Children's Hospital of Philadelphia
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Holly Hedrick
The Children's Hospital of Philadelphia
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Natalie Rintoul
The Children's Hospital of Philadelphia
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Christopher Thom
The Children's Hospital of Philadelphia

Corresponding Author:[email protected]

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Abstract

Pediatric extreme thrombocytosis (EXT, platelet count > 1000 x 103/µL) is rare. In a single center retrospective analysis of hospitalized children with EXT, infants with congenital diaphragmatic hernia (CDH) were overrepresented. In general pediatric patients, EXT is usually secondary to infection or inflammation, but most of the 14 CDH patients with EXT had no identifiable inciting factor. Instead, there was evidence that splenic dysfunction and bone marrow hyperactivity underlied EXT in CDH patients. None were associated with bleeding or thrombosis. Our findings identify mechanisms underlying EXT, and aid clinical interpretation and management of EXT in the pediatric population.