loading page

Study of the Feasibility of the Low-Carbohydrate Ketogenic Diet in Cancer
  • +1
  • Khatereh Pour mohammadi ,
  • Durdana Husain,
  • Tina Vosough,
  • Parisa Chitsaaz
Khatereh Pour mohammadi
Thalassemia & Hemoglobinopathy Research Center, Health research institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Author Profile
Durdana Husain
Ahvaz Jondishapour University of Medical Sciences

Corresponding Author:[email protected]

Author Profile
Tina Vosough
: Thalassemia & Hemoglobinopathy Research Center, Health research institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Author Profile
Parisa Chitsaaz
Thalassemia & Hemoglobinopathy Research Center, Health research institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Author Profile

Abstract

Aim of the Study: The low-carbohydrate ketogenic diet (KD) has been suggested as an adjunct therapy in cancer through its effect on modifying the metabolic milieu of the tumor. The present study was conducted to assess the feasibility of KD in patients with cancer. Materials and Methods: This study was conducted on 53 adult male patients with advanced, metastatic solid tumor cancer in Shafa Oncology Hospital Ahvaz, Iran in the years 2017-2019. The subject followed a low-carbohydrate KD comprised of 10 percent carbohydrates, 20 percent protein, and two-thirds fat. The total amount of carbohydrates per day was 70 grams. The subjects were monitored for possible adverse effects. The body weight, serum levels of glucose, blood urea nitrogen (BUN), and creatinine (Cr.) were measured and body mass index (BMI) was calculated on the 30th, 60th, and 90th day of study. In addition, at each round of measurement, these variables were measured in 21 other patients with advanced cancer following a normal diet Results: Of 53 patients, 10 passed away during the time of the study. Of 43 living patients, 22 (51.16%) dropped out of the study, and 21 (48.84%) continued to the end. No serious adverse effects were reported. No significant differences were detected between the patients following a low-carbohydrate diet and patients following a normal diet in terms of weight, BMI ,creatinine and BUN serum levels. The serum glucose level was 97.43±13.71, 95.81±14.93, and 107.76±37.73 mg/dL in the group of patients following the low-carbohydrate diet and 107.10±31.78, 106.67±34.74, and 99.38±27.48 mg/dL in patients following a normal diet on the 30th, 60th, and 90th day, respectively, with no significant difference between the two groups. Conclusion: Results of the present study support the feasibility of the use of this diet for patients with advanced cancer. Keywords: Cancer, Ketogenic diet, Low-carbohydrate diet, Feasibility