Design of the optical dual-band filter for emission of dual fluorescein
through the irradiation of single optical source
Most brain surgeries aim to completely resection a tumor. However, the
arrangement of blood vessels around brain tumors is often complex.
Moreover, the tumors and blood vessels have similar colors, making it
difficult to identify the boundaries between them with the naked eye.
Fluorescent staining is a method used to distinguish the borders between
brain tumors and blood vessels. The fluorescent contrast agents commonly
used to observe tumors are 5-aminolevulinic acid (5-ALA) and fluorescein
sodium (FS), which have different surgical sensitivities, depending on
the type of tumor. In this article, a dual band band-pass filter (BPF)
with dual-wavelength emission for 5-ALA and FS is designed, and the
dual-band BPF capable of inducing simultaneous fluorescence emission of
FS and 5-ALA was investigated experimentally to improve accuracy, speed,
and energy efficiency in clinical settings. The possibility of dual
fluorescence emission with a single irradiation is proposed. The
proposed fluorescent dual-band filter has the advantage of saving
energy, reducing auxiliary manpower and unit costs, and reducing
operating room space requirements by producing two fluorescence
diagnostic effects using a single equipment.