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Design of the optical dual-band filter for emission of dual fluorescein through the irradiation of single optical source
  • So Yoon Kwon,
  • Ki-Cheol Yoon,
  • Kwang Gi Kim
So Yoon Kwon
Gachon University - Medical Campus
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Ki-Cheol Yoon
Gachon University Gil Medical Center
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Kwang Gi Kim
Gachon University - Medical Campus

Corresponding Author:[email protected]

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Most brain surgeries aim to completely resection a tumor. However, the arrangement of blood vessels around brain tumors is often complex. Moreover, the tumors and blood vessels have similar colors, making it difficult to identify the boundaries between them with the naked eye. Fluorescent staining is a method used to distinguish the borders between brain tumors and blood vessels. The fluorescent contrast agents commonly used to observe tumors are 5-aminolevulinic acid (5-ALA) and fluorescein sodium (FS), which have different surgical sensitivities, depending on the type of tumor. In this article, a dual band band-pass filter (BPF) with dual-wavelength emission for 5-ALA and FS is designed, and the dual-band BPF capable of inducing simultaneous fluorescence emission of FS and 5-ALA was investigated experimentally to improve accuracy, speed, and energy efficiency in clinical settings. The possibility of dual fluorescence emission with a single irradiation is proposed. The proposed fluorescent dual-band filter has the advantage of saving energy, reducing auxiliary manpower and unit costs, and reducing operating room space requirements by producing two fluorescence diagnostic effects using a single equipment.