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Growth Hormone deficiency and Idiopathic short stature. Efficacy after growth hormone treatment up to adult height
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  • Ana Belen Ariza Jimenez,
  • Isabel Leiva Gea,
  • Maria Jose Martinez-Aedo Ollero,
  • Juan Pedro Lopez-Siguero
Ana Belen Ariza Jimenez
Women and Children Hospital Malaga

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Isabel Leiva Gea
Women and Children Hospital Malaga
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Maria Jose Martinez-Aedo Ollero
Women and Children Hospital Malaga
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Juan Pedro Lopez-Siguero
Women and Children Hospital Malaga
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Abstract

Introduction: Diagnostic tests for growth hormone (GH) deficiency, have low specificity, so, it could suppose different results in treatment, because of false positives. Objectives: To evaluate the growth of children with isolated GH deficiency treated with GH in comparison with children with idiopathic short stature treated or not treated. Methods: Ambispective descriptive study of patients under 14 years old treated in our department in the last 14 years for isolated GH deficiency (Group A), in comparison with those diagnosed with idiopathic short stature treated (Group B) and not treated with GH (Group C). Results: 67 male patients were studied in Group A, who showed a gain of total height of 1.24 SD, which was 0.27SD lower than target height. Group B had 30 boys, who showed a gain of height of 1.47SD. There was an improve in final height according to target height of 0.29 SD. 42 boys were studied in Group C. These boys showed an improvement of 0.37 SD from initial height, although they did not reach target height (difference of 0.59 SD). Finally, both treated groups (A and B) showed average final heights (-1.52SD and -1.31SD), while Group C showed shorter final height (-2.03SD). Conclusions: Final height of isolated GH deficiency is similar to those patients with idiopathic short stature treated, without any statistical difference, while both treated groups, were taller than idiopathic short stature non treated.