loading page

The presence of hyperdense middle cerebral artery sign is associated with more new territory emboli
  • Ozlem Aykac,
  • Atilla Ozcan Ozdemir,
  • Utku Cenikli
Ozlem Aykac

Corresponding Author:[email protected]

Author Profile
Atilla Ozcan Ozdemir
Author Profile
Utku Cenikli
Author Profile


Background and Aims: The hyperdense middle cerebral artery sign (HMCAS) on admission non-contrast computed tomography (NCCT) is a well-characterized phenomenon in acute ischemic stroke. The purpose of this study is to determine the impact of HMCAS on the outcome of patients underwent endovascular thrombectomy Method: A retrospective analysis of the prospectively collective database included 136 consecutive patients with anterior circulation acute ischemic stroke who underwent endovascular thrombectomy. We collected the demographics, and clinical and brain imaging as well as functional and imaging outcomes data at baseline. Patients were divided into two groups with hyperdense artery signs and those without the sign. The difference between the two groups in terms of mortality and prognosis was analyzed. Results: There were 136 patients, 50.7 % of them were women. The mean age was 59.1 years. The subgroup with HMCAS present consisted of 93 patients. There were no differences in demographics and clinical characteristics between the two groups, however, tobacco use is more common in patients with HMCAS. No significant difference was observed in clinical outcomes and mortality between the two groups at 3 months. Patients with HMCAS had statistically more new territory emboli during the procedure (9.7%) compared to patients without HMCAS. Conclusion: We showed that the presence of HMCAS in initial CT was not helpful in predicting good clinical outcomes in patients undergoing endovascular therapy patients. However, the presence of HMCAS is related to more new territory embolism during the procedure. Different endovascular strategies may be applied in these patients.