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Effective analysis of platelet transfusion dose in hematological pediatric patients with thrombocytopenia:A single center retrospective cohort study
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  • Qin Liu,
  • Xin Chen,
  • Ling Duan,
  • Ping Chen,
  • Shan Gan,
  • Songli Xie,
  • Hanwei Chen,
  • Jingxing Li,
  • Hongbing Hu
Qin Liu
Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology
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Xin Chen
Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology
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Ling Duan
Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology
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Ping Chen
Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology
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Shan Gan
Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology
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Songli Xie
Wuhan Blood Center
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Hanwei Chen
Wuhan Blood Center
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Jingxing Li
Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology
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Hongbing Hu
Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology

Corresponding Author:[email protected]

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Abstract

Background: Platelet transfusion is a common method to prevent hemorrhage in hematological pediatric patients. There is a shortage of platelet resources in many district of China. Small-dose platelet transfusion may be an effective measure to solve these problems. Methods: A retrospective analysis of platelet transfusion in 96 hematological pediatric patients with thrombocytopenia. According to the actual platelet dosage transfused, we divided the cases into two groups: low-dose platelet transfusion group (<3.0×10^11 platelet/m2, LDC, n=109) and high-dose platelet transfusion group (≥3.0×10^11 platelet/m2, HDC, n=90). To evaluate the effect of platelet transfusion, we assessed the post-transfusion platelet increment (PPI) values, changes of hemoglobin after platelet transfusion and calculated the corrected count increment (CCI) at 24h after transfusion between the two groups. We also recorded adverse reactions during transfusion. Results: Through statistical analysis, we found that there was no statistical difference in the 24h CCI value, hemoglobin change value and the effective rate of platelet transfusion between LDC and HDC groups. There was no adverse reaction in the LDC group, but 1 adverse reaction case in the HDC group. Conclusion: Low dose platelet transfusion is effective in pediatric patients with thrombocytopenia.