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Modular Characteristics and Mechanism for Chinese Medicine Treatment of Gastric cancer, A Data Mining and Pharmacology--Based Identification
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  • Xintian Xu,
  • Yaling Chen,
  • Yonghu Qiang,
  • Mengyun Yuan,
  • Ruijuan Zhang,
  • Xu Chen,
  • Shenlin Liu,
  • Jian Wu,
  • qingmin Sun
Xintian Xu
Nanjing University of Chinese Medicine
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Yaling Chen
Nanjing University of Chinese Medicine
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Yonghu Qiang
Nanjing University of Chinese Medicine
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Mengyun Yuan
Nanjing University of Chinese Medicine
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Ruijuan Zhang
Nanjing University of Chinese Medicine
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Xu Chen
Nanjing University of Chinese Medicine
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Shenlin Liu
Nanjing University of Chinese Medicine
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Jian Wu
Nanjing University of Chinese Medicine
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qingmin Sun
Nanjing University of Chinese Medicine

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Abstract

BACKGROUND AND PURPOSE Traditional Chinese medicine (TCM) is increasingly extensively applied as a complementary therapy for gastric cancer (GC); however, there is a lack of large-scale evidence-based deep learning for the guidance of clinical prescriptions. EXPERIMENTAL APPROACH We collected eligible studies of TCM treatment on GC over the past three decades from China National Knowledge Infrastructure database (CNKI), and established a library of the prescribed herbs with basic attributes. The prescription patterns were explored using association rules mining of IBM SPSS Modeler 18.1, and candidate prescriptions were subsequently explored by deep machine learning. Molecular targets of the candidate clusters were predicted by STITCH, SEA and Swiss. The affinities between bioactive compounds and protein targets of the preferred decoction were confirmed by molecular docking. Mechanisms of the preferred decoction were investigated in vitro and in vivo. KEY RESULTS We extracted 194 clinical trial-based decoctions and found that Atractylodis Mcacrocephalae Rhizoma, Poria and Astragali Radix are the core herbs for treating GC. The preferred decoction for GC is composed of Atractylodis Mcacrocephalae Rhizoma, Astragali Radix, Pinelliae Rhizoma, Citri Reticulatae Pericarpium, Herba Hedyotidis Diffusae, Crataegi Fructus, etc. The predominant bioactive compounds are quercetin, kaempferol, nobiletin, baicalein and luteolin, etc. Moreover, the preferred decoction was indicated to effectively inhibit GC cellular proliferation, invasion and metastasis via hTERT/MDM2-p53 signaling pathway in vivo and in vitro. CONCLUSION AND IMPLICATIONS TCM focusing on invigorating Spleen and tonifying vital-Qi is a promising adjuvant therapy for GC, which offers a guidance of TCM treating GC in worldwide.