Nanomaterials applied in wound healing: mechanisms, limitations and
AbstractInternal and external factors cause various types of wounds on the skin.
Infections, nonhealing chronic wounds, and aesthetic and functional
recovery all cause challenges for clinicians. The development of
nanotechnology in biomedicine has brought many new materials, methods
and therapeutic targets for the treatment of wounds, which are believed
to have great prospects. In this work, the nanomaterials applied in
different stages to promote wound healing and systematically expounded
their mechanisms were reviewed. Then, the difficulties and defects of
the present research and suggested methods for improvement were pointed
out. Moreover, based on the current application status of nanomaterials
in wound treatment, some new ideas for subsequent studies were proposed
and the feasibility of intelligent healing by real-time monitoring,
precision regulation, and signal transmission between electronic signals
and human nerve signals in the future were discussed. This review will
provide valuable directions and spark new thoughts for researchers.