Evaluation of Lung Functions in Preschool-Children Diagnosed with
Transient Tachypnea of the Newborn by Impulse Oscillometry System
Background: Transient tachypnea of the newborn (TTN) is the most common
self-limiting respiratory distress in neonates. There are increasing
data suggesting that TTN may be a risk factor for childhood disease.
Aim: To evaluate lung functions in preschool-children diagnosed with TTN
using Impulse Oscillometry System (IOS) for the presence of respiratory
morbidity. Methods and Patients: In this prospective study,
preschool-children diagnosed with TTN and age-matched healthy children
were defined as TTN-group and control group, and performed IOS.
Resistance (R5-R20), reactance (X5-X20) resonant frequency (Z5), and
reactance area (AX) IOS values were compared in both groups and in
TTN-subgroups. Statistical findings were presented as median (IQR).
Results: A total of 51 preschool-children and 101 healthy controls
participated in study. The rate of asthma diagnosis and wheezing attacks
in TTN-group was found 30.8% and 38.5%, respectively. However, R5
minus R20 was significantly higher, X10, X15 values were significantly
lower in TTN-group than those in controls. Additionally, R5 minus R20
and AX values were significantly higher in late-preterm TTN-subgroup as
compared to term TTN-subgroup. AX was significantly higher in TTN-group
supported with nasal ventilation. R5, R10, R15 and R20 were
significantly higher in TTN-subgroup with history of maternal asthma
compared to TTN-subgroup without that history. R5, R10, R15 and Z5 were
significantly higher and X10, X15, X20 were significantly lower in
TTN-subgroup with passive smoking compared to TTN-subgroup without
passive smoking. Conclusion: Our findings showed peripheral airway
obstruction, a known finding in asthma, among preschool-children
diagnosed with TTN compared to healthy controls.