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Genotoxic and mutagenic evaluation of Ayahuasca in peripheral blood and bone marrow of Mus musculus.
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  • Patrícia Feitosa,
  • Melquisedeque Viana,
  • José Figueredo-Silva,
  • Danniel Ferreira,
  • Maria de Oliveira,
  • André Oliveira,
  • Lucas Leite,
  • Mônica Santos,
  • Maria Silva,
  • Maurício do AMARAL,
  • FABRÍCIO do AMARAL
Patrícia Feitosa
Universidade Estadual do Piaui

Corresponding Author:[email protected]

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Melquisedeque Viana
Universidade Federal do Piaui
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José Figueredo-Silva
Universidade Estadual do Piaui
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Danniel Ferreira
Universidade Estadual do Piaui
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Maria de Oliveira
Universidade Federal do Piaui
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André Oliveira
Universidade Federal do Piauí
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Lucas Leite
Universidade Federal do Piaui
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Mônica Santos
Universidade Estadual Paulista
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Maria Silva
Universidade Federal do Piaui
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Maurício do AMARAL
Universidade Federal do Piaui
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FABRÍCIO do AMARAL
Universidade Estadual do Piaui
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Abstract

Ayahuasca (Santo Daime or Daime tea) is the Quechua name for a tea obtained from the Banisteriopsis caapi vine (B. caapi) with the leaves of the Psychotria viridis (P.viridis) shrub. For generations, this beverage has been used in spiritual rituals by indigenous communities in the Amazon. Its promising neuropharmacological properties and its use as an alternative therapy in medical procedures has generated discussions about its safety. In this context, more experimental investigations must be encouraged so that the scientific data generated can contribute to its more correct use. For this work, we conducted an in vivo investigation of the possible genotoxic and mutagenic effects of ayahuasca. We used peripheral blood (COMET assay) and bone marrow (MN micronucleus test) from Mus musculus after oral administration of the tea. The results did not indicate genotoxic effects for the COM assay (tail length and percentage of DNA) when compared to the negative control, nor mutagenic effects for the MN test. Therefore, we found no evidence of genotoxicity or mutagenicity that reinforces the discussion about the harmful effects of this beverage.