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Pterostilbene inhibits influenza virus infection through interaction with NS1 protein
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  • Wenjiao Wu,
  • Yilu Ye,
  • Yingyuan Zhong,
  • Xiukui Yan,
  • Jianguo Lin,
  • Zhi Zhang,
  • Shuwen Liu,
  • Li Chen
Wenjiao Wu
Guangdong Second Provincial General Hospital

Corresponding Author:[email protected]

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Yilu Ye
Southern Medical University
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Yingyuan Zhong
Jiangmen Central Hospital
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Xiukui Yan
Guangdong Second Provincial General Hospital
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Jianguo Lin
Guangdong Second Provincial General Hospital
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Zhi Zhang
Guangdong Second Provincial General Hospital
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Shuwen Liu
Southern Medical University
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Li Chen
Guangdong Second Provincial General Hospital
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Abstract

With the prevalence of novel influenza strain and drug resistance virus, it is urgent to develop effective and low-toxicity anti-influenza therapeutics. Here we found that pterostilbene effectively inhibited influenza A virus infection. Mechanism study demonstrated that pterostilbene inhibited virus infection through interaction with influenza non-structural protein 1 (NS1), in turn promoted the induction of antiviral type I interferon and impeded the pro-viral PI3K/Akt pathway activation during influenza virus infection, inducing a synergistic inhibitory effect against influenza virus infection. Thus, pterostilbene can be a promising anti-influenza agent for the future antiviral drug exploitation.