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Behavioral toxicity and pharmacokinetics of PCB 77 and PCB 180 in Swiss albino mouse: A single dose inhalation toxicity risk assessment
  • RAMANUJAM NARAYANAN,
  • SIVASELVAKUMAR MUTHUSAMY,
  • RAMALINGAM SANKARAN
RAMANUJAM NARAYANAN
PSG Institute of Medical Sciences and Research
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SIVASELVAKUMAR MUTHUSAMY
PSG Institute of Medical Sciences and Research
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RAMALINGAM SANKARAN
PSG Institute of Medical Sciences and Research

Corresponding Author:[email protected]

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Abstract

Polychlorinated Biphenyls (PCBs) pose health hazards to humans as environmental and occupational workplace pollutants. The pharmacokinetics and behavioral effects of PCBs after inhalation exposures of Aroclor 1232 in Swiss albino mice were assessed in this study, and these effects correlate with monoamine levels in brain. A whole-body inhalation chamber has been utilized to expose mice to different doses of Aroclor 1232 for single six-hour durations. The plasma and brain samples were used to estimate the corresponding concentration-time profiles of two representative congeners of PCBs (PCB 77 and PCB 180) and calculate their pharmacokinetic parameters. These variables were then correlated with mouse behavior using Irwin scale, and monoamine levels. A definite dose-dependence of PCB 77 and PCB 180 pharmacokinetic parameters was identified in plasma and brain. PCB 77 exhibited more accumulation in brain than plasma, whereas PCB 180 accumulated more in plasma than brain. Mood, autonomic scores, and miscellaneous sub domains were significantly different from control group scores, correlated with brain monoamine levels. Single duration-exposure toxicity and generation of PCB 77 and PCB 180 pharmacokinetic parameters in mouse brain and plasma after inhalation dosing of Aroclor 1232 have been successfully accomplished. The brain to plasma ratio was correlated to behavioral disruption in mice suggesting PCBs can alter monoamine levels. Finally, the study results could be used to extrapolate and model neurobehavioral risk hazards at human workplace occupational exposures to PCB mixtures, both indoor and outdoor.