Aim: The aim of this study is to investigate the effect of colchicine on
contrast induced nephropathy(CIN). Methods: 42 female rats were included
in the study. Group1 rats were not subjected to any process. Grup2 rats
were given contrast alone. Group3 rats were administered 50μg/kg/day
oral colchicine 12 hours before contrast administration and
simultaneously with contrast. Group4 rats were given 100μg/kg/day oral
colchicine 12 hours before contrast administration and simultaneously
with contrast. Group5 rats were given 50μg/kg/day oral colchicine
simultaneously with contrast. Group6 rats were administered 100μg/kg/day
oral colchicine simultaneously with contrast. Blood samples were
collected before administration of contrast and post-contrast 48th hour,
and blood urea nitrogen and creatinine levels were studied. At the same
time, kidney tissue were taken and evaluated histopathologically.
Results: It was found that CIN was not developed in Group1 and the
groups administered contrast+colchicine. CIN was observed by 28.5% in
the group administered contrast alone. Mild tubular degeneration was
found in Group2 compared to the other groups(p<0.001).
Evaluating for tubular necrosis and congestion, mild damage was seen in
all groups, while moderate damage was observed in Group2(p=0.05).
Conclusion: CIN was not developed in the groups administered colchicine.
Colchicine may be effective in preventing CIN.