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The Effect of colchicine on the prevention of contrast induced nephropathy
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  • Yasemin Kaya,
  • Orhan Bas,
  • Ahmet Kaya,
  • Ahmet Karakas,
  • Havva ERDEM,
  • Ilhan Irende,
  • Ebru Canakci,
  • Harun Dugeroglu
Yasemin Kaya

Corresponding Author:[email protected]

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Orhan Bas
Ordu University
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Ahmet Kaya
Ordu Universitesi Tip Fakultesi
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Ahmet Karakas
Ordu Universitesi Tip Fakultesi
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Havva ERDEM
Ordu University
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Ilhan Irende
Karadeniz Technical University
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Ebru Canakci
Ordu University
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Harun Dugeroglu
Ordu University
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Abstract

Aim: The aim of this study is to investigate the effect of colchicine on contrast induced nephropathy(CIN). Methods: 42 female rats were included in the study. Group1 rats were not subjected to any process. Grup2 rats were given contrast alone. Group3 rats were administered 50μg/kg/day oral colchicine 12 hours before contrast administration and simultaneously with contrast. Group4 rats were given 100μg/kg/day oral colchicine 12 hours before contrast administration and simultaneously with contrast. Group5 rats were given 50μg/kg/day oral colchicine simultaneously with contrast. Group6 rats were administered 100μg/kg/day oral colchicine simultaneously with contrast. Blood samples were collected before administration of contrast and post-contrast 48th hour, and blood urea nitrogen and creatinine levels were studied. At the same time, kidney tissue were taken and evaluated histopathologically. Results: It was found that CIN was not developed in Group1 and the groups administered contrast+colchicine. CIN was observed by 28.5% in the group administered contrast alone. Mild tubular degeneration was found in Group2 compared to the other groups(p<0.001). Evaluating for tubular necrosis and congestion, mild damage was seen in all groups, while moderate damage was observed in Group2(p=0.05). Conclusion: CIN was not developed in the groups administered colchicine. Colchicine may be effective in preventing CIN.