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Neutrophil:lymphocyte ratio as a potential predictor of the pregnancy outcome in women with threatened late miscarriage: a retrospective cohort study
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  • Xiaoying Lin,
  • Rong Li,
  • Cheng Huang,
  • Le Zhang,
  • Qiuxian Mao,
  • Daihua Lin,
  • Lvyin Huang,
  • Zhen Gao,
  • Huoying Chen,
  • Jiaxue Wei
Xiaoying Lin
Guangdong Second Provincial General Hospital
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Rong Li
Guangdong Second Provincial General Hospital
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Cheng Huang
Guangdong Second Provincial General Hospital
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Le Zhang
Guangdong Second Provincial General Hospital
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Qiuxian Mao
Guangdong Second Provincial General Hospital
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Daihua Lin
Guangdong Second Provincial General Hospital
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Lvyin Huang
Guangdong Second Provincial General Hospital
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Zhen Gao
Guangdong Second Provincial General Hospital
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Huoying Chen
Guangdong Second Provincial General Hospital

Corresponding Author:[email protected]

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Jiaxue Wei
Guangdong Second Provincial General Hospital
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Abstract

Objectives: To assesses the value of systemic inflammatory markers in evaluating the prognosis of threatened late miscarriage (TLM) patients. Design: Retrospective study. Setting: Single tertiary center. Population: A cohort of 220 TLM patients (128 remained pregnant until delivery and 92 developed into inevitable miscarriage (IM)) from January 2015 to August 2020, in addition to a control group of 200 normal pregnancies. Methods: Using routinely collected clinical data. Main Outcome Measures: Data of characteristics at baselines, complete blood counts and neonatal outcomes of live births. Predictive value of neutrophil:lymphocyte ratio (NLR) for the pregnancy outcome of TLM. Results: The mean counts for the total white blood cells (WBCs) and neutrophils in women with TLM increased and exceeded the reference ranges, resulting in a significant increase NLR. The counts for the total WBCs and neutrophils exceeding the upper limit were present in approximately 66% and 82% of TLM pregnancies, respectively. Besides, the prevalence of adverse neonatal outcomes was higher in the live-birth group of TLM. In TLM pregnancies, the NLR of the IM group was significantly higher than that of the live-birth group, and NLR showed considerable value in diagnosing IM (area under the curve = 0.67, sensitivity = 55.44%, specificity = 77.34%). A cutoff value of NLR > 6.05 indicated an increased risk of IM. Conclusion: Higher NLR in TLM pregnancies indicates that systemic inflammation may be involved in TLM progression, and the NLR value obtained at the initial stage of TLM has potential predictive value for the outcome of TLM.