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FISETIN – A PROSPECTIVE NEUROPROTECTIVE AGENT WITH MULTI-MOLECULAR TARGET ‘S: A REVIEW
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  • Arun reddy Ravula,
  • Suraj Benerji Teegala,
  • Jagadeesh prasad Pasangulapati,
  • Venkatesan Perumal,
  • Shanker Kalakotla,
  • Hemanth kumar Boyina
Arun reddy Ravula
Anurag Group of Institutions
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Suraj Benerji Teegala
Anurag Group of Institutions
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Jagadeesh prasad Pasangulapati
Treventis Corporation
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Venkatesan Perumal
Texas A&M University Kingsville - Irma Lerma Rangel College of Pharmacy
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Shanker Kalakotla
JSS Academy of Higher Education and Research, JSS College of Pharmacy
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Hemanth kumar Boyina
Anurag University

Corresponding Author:[email protected]

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Abstract

Fisetin (3, 3′, 4′, 7-tetrahydroxyflavone) belongs to class of flavonoids which is abundant in several fruits and vegetables that we consume daily. Fisetin has manifested several health benefits in preclinical models of neurodegenerative diseases: Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, stroke (both ischemic and hemorrhagic), traumatic brain injury and age-associated changes (physiological and pathological). The main aim of this present paper is to evaluate the role of fisetin in treating several neurological diseases which is attributed to its simultaneous targeting of various molecular pathways. This review provides a comprehensive mechanistic pathway’s pertaining to fisetin role in treating several neurological and neurodegenerative diseases.