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Sex-specific reference limits of left ventricular ejection fraction and volumes estimated by gated myocardial perfusion imaging for low-likehood patients in China: a comparison between three quantitative software
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  • Jiajun Li,
  • Xiangyi Chen,
  • Jingzhe Liu,
  • Wei Fang,
  • Dawei Wang,
  • Zuo-Xiang He
Jiajun Li
Beijng Huaxin Hospital First Hospital of Tsinghua University
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Xiangyi Chen
Yichang Central People's Hospital
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Jingzhe Liu
Beijng Huaxin Hospital First Hospital of Tsinghua University
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Wei Fang
Fuwai Hospital State Key Laboratory of Cardiovascular Disease
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Dawei Wang

Corresponding Author:[email protected]

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Zuo-Xiang He
Tsinghua University Affiliated Beijing Tsinghua Changgung Hospital
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Our aim was to derive male and female reference limits of left-ventricular functional parameters for patients with low-likehood coronary heart disease using three quantitative methods and determined the effect of gender, age and body weight on cardiac functional parameters. One hundred and seventy-five consecutive patients who defined as low-likehood coronary heart disease patients underwent adenosine or exercise stress 99mTc-MIBI gated myocardial perfusion single photon emission computed tomography (SPECT) imaging, left ventricular (LV) ejection fraction (EF),end-diastolic volume (EDV),and end-systolic volume (ESV) were obtained by QGS, ECToolbox and 4D-MSPECT, respectively. LVEF and LV volumes determined by gated SPECT are significantly affected by gender and age, with body weight as a significant predictor for cardiac volumes. The values of EDV and EF determined by three methods could be different although they correlate very well; the reference limit of EDV, ESV and EF calculated by three methods are established.